A growing subset of metalloenzymes activates dioxygen with nonheme diiron active sites to
effect substrate oxidations that range from the hydroxylation of methane and the …

In recent years, significant progress has been made in understanding the geometric and
electronic structures of the active sites of non-heme iron enzymes and the contributions of …

Life on earth is dependent on the catalytic activity of a number of different metal ions in their
polypeptide scaffold. Of these metals iron is widely used for catalysis of many reactions by …

Stearoyl-CoA desaturase (SCD) is conserved in all eukaryotes and introduces the first
double bond into saturated fatty acyl-CoAs,,,. Because the monounsaturated products of …

The controlled oxidation of methane to methanol is a chemical transformation of great value,
particularly in the pursuit of alternative fuels, but the reaction remains underutilized …

Methanotrophic bacteria are capable of using methane as their sole source of carbon and
energy. The first step in methane metabolism, the oxidation of methane to methanol, is …

Isoprenoids represent the oldest class of known low molecular-mass natural products
synthesized by plants. Their biogenesis in plastids, mitochondria and the endoplasmic …

Ribonucleotide reductase (RNR) is the enzyme responsible for the conversion of
ribonucleotides to 2′-deoxyribonucleotides and thereby provides the precursors needed …

Ferritins are spherical, cage-like proteins with nanocavities formed by multiple polypeptide
subunits (four-helix bundles) that manage iron/oxygen chemistry. Catalytic coupling yields …

The authors describe basic theoretical concepts of vibrational spectroscopy, address
instrumental aspects and experimental procedures, and discuss experimental and …