Various mechanisms in the mammalian body provide resilience against food deprivation
and dietary stress. The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from …

Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier
of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also …

Dietary and metabolic therapies have been attempted in a wide variety of neurological
diseases, including epilepsy, headache, neurotrauma, Alzheimer disease, Parkinson …

Ketones (principally β-hydroxybutyrate and acetoacetate (AcAc)) are an important
alternative fuel to glucose for the human brain, but their utilisation by the brain remains …

Abstract β-Hydroxybutyrate, a ketone body that is used as an energy source in organs such
as the brain, muscle, and heart when blood glucose is low, is produced by fatty acid …

Epidemiological and biochemical studies show that the sporadic forms of Alzheimer's
disease (AD) are characterized by the following hallmarks:(a) An exponential increase with …

Ketone bodies (KBs), acetoacetate and β-hydroxybutyrate (βHB), were considered harmful
metabolic by-products when discovered in the mid-19th century in the urine of patients with …

Within the past two decades, interest in understanding the therapeutic mechanisms of
ketogenic diet (KD) action has grown steadily. Expanded knowledge about underlying …

Background Alzheimer's disease (AD) is a devastating neurodegenerative ailment having
pathological hallmarks of plaques due to amyloid β (Aβ) peptides and neurofibrillary tangles …

The fruit fly Drosophila melanogaster is increasingly utilized as an alternative to costly
rodent models to study human diseases. Fly models exist for a wide variety of human …