The formula GFR= kL/Pcr can be used to estimate GFR in infants, children, and adolescents
who have grossly normal body habitus and are in steady-state condition. GFR is expressed …

Growth and development can be investigated using readily observable demographic factors
such as weight and age. Size is the primary covariate and can be referenced to a 70-kg …

Provide the best care possible with expert insight and clinically relevant coverage of the
physiologic changes that occur throughout all major periods of the perinatal experience …

Many physiologic differences between children and adults may result in age-related
changes in pharmacokinetics and pharmacodynamics. Factors such as gastric pH and …

The kidney plays a vital role in the body's defense against potentially toxic xenobiotics and
metabolic waste products through elimination pathways. In particular, secretory transporters …

This study pools published data to describe the increase in glomerular filtration rate (GFR)
from very premature neonates to young adults. The data comprises measured GFR (using …

An estimate of glomerular filtration rate has been derived for children from body length (L,
incentimeters) and plasma creatinine (Pcr, in milligrams per deciliter): GFR= 0.55 L/Pcr. The …

Acute kidney injury (AKI) is an under-recognized morbidity of neonates; the incidence
remains unclear due to the absence of a unified definition of AKI in this population and …

AIM To establish a reference range in the paediatric population for the new glomerular
filtration rate (GFR) marker, cystatin C, and to compare it with that of creatinine. METHODS …

• The systemic manifestations of" asphyxia" were evaluated prospectively in 35
consecutively intubated term newborn infants. The following systemic organ injuries were …