Epigenetic landscape of small cell lung cancer: small image of a giant recalcitrant disease
Small cell lung cancer (SCLC) is a particular subtype of lung cancer with high mortality.
Recent advances in understanding SCLC genomics and breakthroughs of immunotherapy …
Recent advances in understanding SCLC genomics and breakthroughs of immunotherapy …
RUNX1T1 function in cell fate
N Hu, L Zou, C Wang, G Song - Stem Cell Research & Therapy, 2022 - Springer
Abstract RUNX1T1 (Runt-related transcription factor 1, translocated to 1), a myeloid
translocation gene (MTG) family member, is usually investigated as part of the fusion protein …
translocation gene (MTG) family member, is usually investigated as part of the fusion protein …
Plasticity in the absence of NOTCH uncovers a RUNX2-dependent pathway in small cell lung cancer
Neuroendocrine to nonneuroendocrine plasticity supports small cell lung cancer (SCLC)
tumorigenesis and promotes immunogenicity. Approximately 20% to 25% of SCLCs harbor …
tumorigenesis and promotes immunogenicity. Approximately 20% to 25% of SCLCs harbor …
[HTML][HTML] Comprehensive genomic profiling of Finnish lung adenocarcinoma cohort reveals high clinical actionability and SMARCA4 altered tumors with variable …
EM Talvitie, L Liljeroos, H Vilhonen, K Orte, I Leivo… - Neoplasia, 2022 - Elsevier
Introduction Lung adenocarcinoma is the most common type of lung cancer and typically
carries a high number of mutations. However, the genetic background of the tumors varies …
carries a high number of mutations. However, the genetic background of the tumors varies …
The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis
MYCN oncogene amplification is frequently observed in aggressive childhood
neuroblastoma. Using an unbiased large-scale mutagenesis screen in neuroblastoma …
neuroblastoma. Using an unbiased large-scale mutagenesis screen in neuroblastoma …
Functional drug screening of small molecule inhibitors of epigenetic modifiers in refractory AML patients
Simple Summary Acute myeloid leukemia is a cancer originating in the bone marrow and
peripheral blood. Genetic mutations observed with the disease are difficult to target …
peripheral blood. Genetic mutations observed with the disease are difficult to target …
Molecular profiling of non-small-cell lung cancer patients with or without brain metastases included in the randomized SAFIR02-LUNG trial and association with …
Introduction Lung cancer remains the most frequent cause of brain metastases (BMs) and is
responsible for high morbidity and mortality. Intracranial response to systemic treatments is …
responsible for high morbidity and mortality. Intracranial response to systemic treatments is …
RUNX1T1, a potential prognostic marker in breast cancer, is co-ordinately expressed with ERα, and regulated by estrogen receptor signalling in breast cancer cells
Background RUNX1T1 is extensively studied in the context of AML1-RUNX1T1 fusion
protein in acute myeloid leukemia. Little is known about the function of RUNX1T1 itself …
protein in acute myeloid leukemia. Little is known about the function of RUNX1T1 itself …
Prediction of Impairment Biomarkers in Smoker Based on Machine Learning
C Chen, D Lv, N Zhang, H Yang… - 2023 3rd …, 2023 - ieeexplore.ieee.org
Smoking is one of the major health issues globally, causing up to 7 million deaths each year.
This paper aimed to predict impairment biomarkers in smoker based on machine learning …
This paper aimed to predict impairment biomarkers in smoker based on machine learning …
Cancer Biomarkers in the Era of Systems Biology
Cancer biomarkers allow diagnosis, risk assessment, monitoring disease progression, and
prediction of therapeutic response in oncology. Different forms and types of cancer …
prediction of therapeutic response in oncology. Different forms and types of cancer …