DNA and RNA can fold into a variety of alternative conformations. In recent years, a
particular nucleic acid structure was discussed to play a role in malignant transformation and …

Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …

Activating KRAS mutations frequently occur in pancreatic, colorectal, and lung
adenocarcinomas. While many attempts have been made to target oncogenic KRAS, no …

KRAS is one of the most mutated genes in human cancer. It is controlled by a G4 motif
located upstream of the transcription start site. In this paper, we demonstrate that 8 …

Background G-rich sequences undergo unique structural equilibria to form G-quadruplexes
(G4) both in vitro and in cell systems. Several pathologies emerged to be directly related to …

The role of non-duplex DNA, the guanine-quadruplex structure in particular, is becoming
widely appreciated. Increasing evidence in the last decade implicates quadruplexes in …

In mammalian cells, cell cycle entry occurs in response to the correct stimuli and is promoted
by the transcriptional activity of E2F family members. E2F proteins regulate the transcription …

Abstract Integrin-linked kinase (ILK), which is an ankyrin repeat-containing serine/threonine
protein kinase, interacts with integrin β1 and the β3 cytoplasmic domain and phosphorylates …

Endometrial cancer represents one of the most common gynecological tumors in the world.
Advanced and relapsed patients rely on drug therapy. Therefore, it is extremely important to …

G-quadruplexes are four-stranded conformations of nucleic acids that act as cellular
epigenetic regulators. A dynamic G-quadruplex forming region in the HIV-1 LTR promoter …