Research studies focusing on various aspects of carcinogenesis in the background of
fibrosis have advanced significantly in the recent past, allowing us to understand the …

Oral cancer is one of the most frequent malignant diseases worldwide, and areca nut is a
primary carcinogen causing this cancer in Southeast Asia. It has been widely reported that …

Autophagy has been shown to be critically associated with the central mechanisms
underlying Parkinson's disease (PD), while the mechanisms contributing to the imbalance of …

Oral cancers (OC) are among the most frequent malignancies encountered in Southeast
Asia, primarily due to the prevalent habit of betel quid (BQ) and smokeless tobacco use in …

Background IARC has classified the betel nut as a human environmental carcinogen.
Previous studies have found that arecoline (AR) is the major alkaloid present in the saliva of …

Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca
nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian …

Elevated oxidative stress in cancer cells contributes to hyperactive proliferation and
enhanced survival, which can be exploited using agents that increase reactive oxygen …

Oral submucous fibrosis (OSF) is a chronic premalignant disease associated with betel quid
chewing. Epidemiological studies indicate that there are approximately 5 million individuals …

Osteosarcoma (OS) is the most common primary bone tumor, but molecular mechanisms of
the disease have not been well understood, and treatment of metastatic OS remains a …

Background: Oridonin (ORI) could inhibit the proliferation and induce apoptosis in various
cancer cell lines. However, the mechanism is not fully understood. Methods: Human prostate …