Ubiquitin-like protein conjugation: structures, chemistry, and mechanism
L Cappadocia, CD Lima - Chemical reviews, 2018 - ACS Publications
Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …
Protein neddylation and its alterations in human cancers for targeted therapy
L Zhou, W Zhang, Y Sun, L Jia - Cellular signalling, 2018 - Elsevier
Neddylation, a post-translational modification that conjugates an ubiquitin-like protein
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …
Emerging mechanisms of aminoacyl-tRNA synthetase mutations in recessive and dominant human disease
R Meyer-Schuman, A Antonellis - Human molecular genetics, 2017 - academic.oup.com
Aminoacyl-tRNA synthetases (ARSs) are responsible for charging amino acids to cognate
tRNA molecules, which is the essential first step of protein translation. Interestingly …
tRNA molecules, which is the essential first step of protein translation. Interestingly …
[HTML][HTML] Roles of aminoacyl-tRNA synthetases in cancer
Z Zhou, B Sun, A Nie, D Yu, M Bian - Frontiers in cell and …, 2020 - frontiersin.org
Aminoacyl-tRNA synthetases (ARSs) catalyze the ligation of amino acids to their cognate
transfer RNAs (tRNAs), thus playing an important role in protein synthesis. In eukaryotic …
transfer RNAs (tRNAs), thus playing an important role in protein synthesis. In eukaryotic …
[HTML][HTML] Protein neddylation and its role in health and diseases
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …
The role of tRNA synthetases in neurological and neuromuscular disorders
Aminoacyl‐tRNA synthetases (ARS s) are ubiquitously expressed enzymes responsible for
charging tRNA s with their cognate amino acids, therefore essential for the first step in …
charging tRNA s with their cognate amino acids, therefore essential for the first step in …
[HTML][HTML] NEDD8-conjugating enzyme E2s: critical targets for cancer therapy
L Zhou, X Lin, J Zhu, L Zhang, S Chen, H Yang… - Cell Death …, 2023 - nature.com
Abstract NEDD8-conjugating enzymes, E2s, include the well-studied ubiquitin-conjugating
enzyme E2 M (UBE2M) and the poorly characterized ubiquitin-conjugating enzyme E2 F …
enzyme E2 M (UBE2M) and the poorly characterized ubiquitin-conjugating enzyme E2 F …
[HTML][HTML] Anticancer drug discovery by targeting cullin neddylation
Q Yu, Y Jiang, Y Sun - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Protein neddylation is a post-translational modification which transfers the ubiquitin-like
protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic …
protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic …
Targeting protein neddylation for cancer therapy
L Zhou, L Jia - Cullin-RING Ligases and Protein Neddylation: Biology …, 2020 - Springer
Neddylation is a posttranslational modification that conjugates a ubiquitin-like protein
NEDD8 to substrate proteins. The best-characterized substrates of neddylation are the cullin …
NEDD8 to substrate proteins. The best-characterized substrates of neddylation are the cullin …
Predicting the pathogenicity of aminoacyl-tRNA synthetase mutations
SN Oprescu, LB Griffin, AA Beg, A Antonellis - Methods, 2017 - Elsevier
Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed, essential enzymes
responsible for charging tRNA with cognate amino acids—the first step in protein synthesis …
responsible for charging tRNA with cognate amino acids—the first step in protein synthesis …