[HTML][HTML] CRISPR-Cas9: a preclinical and clinical perspective for the treatment of human diseases
G Sharma, AR Sharma, M Bhattacharya, SS Lee… - Molecular Therapy, 2021 - cell.com
At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …
research era. Genome modification studies have traveled a long way from gene …
[HTML][HTML] Beyond repression of Nrf2: An update on Keap1
Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …
[HTML][HTML] Structural basis of Keap1 interactions with Nrf2
P Canning, FJ Sorrell, AN Bullock - Free Radical Biology and Medicine, 2015 - Elsevier
Keap1 is a highly redox-sensitive member of the BTB-Kelch family that assembles with the
Cul3 protein to form a Cullin–RING E3 ligase complex for the degradation of Nrf2. Oxidative …
Cul3 protein to form a Cullin–RING E3 ligase complex for the degradation of Nrf2. Oxidative …
Artemisinin action and resistance in Plasmodium falciparum
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …
Kelch-like protein 11 antibodies in seminoma-associated paraneoplastic encephalitis
C Mandel-Brehm, D Dubey, TJ Kryzer… - … England Journal of …, 2019 - Mass Medical Soc
A 37-year-old man with a history of seminoma presented with vertigo, ataxia, and diplopia.
An autoantibody specific for kelch-like protein 11 (KLHL11) was identified with the use of …
An autoantibody specific for kelch-like protein 11 (KLHL11) was identified with the use of …
CUL3 (cullin 3)-mediated ubiquitination and degradation of BECN1 (beclin 1) inhibit autophagy and promote tumor progression
X Li, KB Yang, W Chen, J Mai, XQ Wu, T Sun, RY Wu… - Autophagy, 2021 - Taylor & Francis
Macroautophagy/autophagy plays an important role during the development of human
cancer. BECN1 (beclin 1), a core player in autophagy regulation, is downregulated in many …
cancer. BECN1 (beclin 1), a core player in autophagy regulation, is downregulated in many …
Characterizations of three major cysteine sensors of Keap1 in stress response
R Saito, T Suzuki, K Hiramoto, S Asami… - … and cellular biology, 2016 - Am Soc Microbiol
Abstract The Keap1-Nrf2 system plays a central role in cytoprotection against
electrophilic/oxidative stresses. Although Cys151, Cys273, and Cys288 of Keap1 are major …
electrophilic/oxidative stresses. Although Cys151, Cys273, and Cys288 of Keap1 are major …
Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas
Constitutional SMARCB1 mutations at 22q11. 23 have been found in∼ 50% of familial and<
10% of sporadic schwannomatosis cases. We sequenced highly conserved regions along …
10% of sporadic schwannomatosis cases. We sequenced highly conserved regions along …
[HTML][HTML] MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation
J Ma, L Li, B Ma, T Liu, Z Wang, Q Ye, Y Peng… - Nature …, 2024 - nature.com
Abstract CDK4/6 inhibitors (CDK4/6i) show anticancer activity in certain human
malignancies, such as breast cancer. However, their application to other tumor types and …
malignancies, such as breast cancer. However, their application to other tumor types and …
Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility
Z Lin, S Li, C Feng, S Yang, H Wang, D Ma, J Zhang… - Nature …, 2016 - nature.com
Skin integrity is essential for protection from external stress and trauma. Defects in structural
proteins such as keratins cause skin fragility, epitomized by epidermolysis bullosa (EB), a …
proteins such as keratins cause skin fragility, epitomized by epidermolysis bullosa (EB), a …