At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …

Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …

Keap1 is a highly redox-sensitive member of the BTB-Kelch family that assembles with the
Cul3 protein to form a Cullin–RING E3 ligase complex for the degradation of Nrf2. Oxidative …

The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …

A 37-year-old man with a history of seminoma presented with vertigo, ataxia, and diplopia.
An autoantibody specific for kelch-like protein 11 (KLHL11) was identified with the use of …

Macroautophagy/autophagy plays an important role during the development of human
cancer. BECN1 (beclin 1), a core player in autophagy regulation, is downregulated in many …

Abstract The Keap1-Nrf2 system plays a central role in cytoprotection against
electrophilic/oxidative stresses. Although Cys151, Cys273, and Cys288 of Keap1 are major …

Constitutional SMARCB1 mutations at 22q11. 23 have been found in∼ 50% of familial and<
10% of sporadic schwannomatosis cases. We sequenced highly conserved regions along …

Abstract CDK4/6 inhibitors (CDK4/6i) show anticancer activity in certain human
malignancies, such as breast cancer. However, their application to other tumor types and …

Skin integrity is essential for protection from external stress and trauma. Defects in structural
proteins such as keratins cause skin fragility, epitomized by epidermolysis bullosa (EB), a …