This document is an update of the British Sarcoma Group guidelines (2016) and provides a
reference standard for the clinical care of UK patients with primary malignant bone tumours …

Chordomas are rare, malignant bone tumors of the skull-base and axial skeleton. Until
recently, there was no consensus among experts regarding appropriate clinical …

Chordomas are very rare bone malignant tumours that have had a shortage of effective
treatments for a long time. New treatments are now available for both the local and the …

Chordoma is a rare bone tumor with an unknown etiology and high recurrence rate. Here we
conduct whole genome sequencing of 80 skull-base chordomas and identify PBRM1, a …

Spine tumors comprise a small percentage of reasons for back pain and other symptoms
originating in the spine. The majority of the tumors involving the spinal column are …

Purpose To explore the antitumor activity of imatinib in patients with advanced platelet-
derived growth factor β (PDGFB)/PDGF receptor β (PDGFRB)–positive chordomas. Patients …

Chordomas are rare, slowly growing, locally aggressive neoplasms of bone that arise from
embryonic remnants of the notochord. These tumors typically occur in the axial skeleton and …

Metastatic disease, myeloma, and lymphoma are the most common malignant spinal tumors.
Hemangioma is the most common benign tumor of the spine. Other primary osseous lesions …

Background and aims The aim of this systematic review is to describe the epidemiology of
chordoma and to provide a clear overview of clinical prognostic factors predicting …

Chordoma is a low-grade notochordal tumor of the skull base, mobile spine and sacrum
which behaves malignantly and confers a poor prognosis despite indolent growth patterns …