Pet dogs develop spontaneous cancers at a rate estimated to be five times higher than that
of humans, providing a unique opportunity to study disease biology and evaluate novel …

The recent advances in high‐throughput next‐generation sequencing technologies have
heralded the arrival of the Big Data era. As a result, the use of pharmacogenetics in drug …

Epithelial cells have an ability termed 'cell competition', which is an immune surveillance-like
function that extrudes precancerous cells from the epithelial layer, leading to apoptosis and …

Polymorphisms of canine leukocyte antigen (DLA) class I (DLA-88 and DLA-12/88L) and
class II (DLA-DRB1) genes are important for disease susceptibility studies, but information …

CD4+ T cells are an integral component of the adaptive immune response, carrying out
many functions to combat a diverse range of pathogenic challenges. These cells exhibit …

Background Recently, mesenchymal stem cells therapy has been performed in dogs,
although the outcome is not always favorable. Objectives To investigate the therapeutic …

DLA-88 is a classical major histocompatibility complex (MHC) class I gene in dogs, and
allelic DLA-88 molecules have been divided into two categories named “DLA-88* 0” and …

Canine chronic enteropathy (CE) is a group of immunogenetic disorders of unclear etiology
characterized by chronic or recurrent gastrointestinal signs and inflammation. Diagnosis of …

The dog leukocyte antigen (DLA) class I genomic region is located on chromosome 12, and
the class I genomic region is composed of at least two distinct haplotypic gene structures …

As targeted personalized therapy becomes more widely used in human medicine, clients
will expect the veterinary clinician to be able to implement an evidence-based strategy …