Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …

The dysregulation of energy homeostasis in obesity involves multihormone resistance.
Although leptin and insulin resistance have been well characterized, catecholamine …

This review addresses open questions about the role of β-adrenergic receptors in cardiac
function and failure. Cardiomyocytes express all three β-adrenergic receptor subtypes—β1 …

β 3-Adrenergic receptors (β 3-ARs) are expressed predominantly in white and brown
adipose tissue, and β 3-selective agonists are potential anti-obesity drugs. However, the role …

The beta-3 adrenergic receptor (β3-AR) is by far the least studied isotype of the beta-
adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal …

Adrenergic receptors for adrenaline and noradrenaline belong to the large multigenic family
of receptors coupled to GTP‐binding proteins. Three pharmacologic types have been …

Cardiac fibrosis is characterized by the deposition of extracellular matrix proteins in the
spaces between cardiomyocytes following both acute and chronic tissue damage events …

Signalling is one of the key processes in biological systems. It enables communication
within a single cell as well as among the many cells in higher organisms. Specialized …

The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after
the observation of its expression in white and beige human adipocytes and its implication in …