Forkhead box O (FoxO) transcription factors are downstream targets of the serine/threonine
protein kinase B (PKB)/Akt. The Akt kinase regulates processes of cellular proliferation and …

Iron-dependent lipid peroxidation causes ferroptosis, a form of regulated cell death. Crucial
steps in the formation of ferroptosis include the accumulation of ferrous ions (Fe2+) and lipid …

The tumor suppressor p53 is one of the most frequently mutated genes in human cancers.
MicroRNAs (miRNAs) are small non-protein coding RNAs that regulate gene expression on …

The world is complex, but acknowledging its complexity requires an appreciation for the
many roles context plays in shaping natural phenomena. In Unsimple Truths, Sandra …

The p53 pathway is composed of hundreds of genes and their products that respond to a
wide variety of stress signals. These responses to stress include apoptosis, cellular …

In response to stress, p53 initiates the transcriptional regulation of selected target genes and
various cellular responses, including cell cycle arrest, apoptosis and senescence. Recent …

In the recent years, knowledge about cancer biomarkers has increased tremendously
providing great opportunities for improving the management of cancer patients by …

The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor
is a phosphatase that antagonizes the phosphoinositol-3-kinase/AKT signaling pathway and …

Tumor suppressor p53 plays a central role in tumor prevention. As a transcription factor, p53
mainly exerts its function through transcription regulation of its target genes to initiate various …

The p53 tumor suppressor is a transcriptional activator, with discrete domains that
participate in sequence-specific DNA binding, tetramerization, and transcriptional activation …