Abstract E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial
sheets. Through the homophilic association of E-Cadherin molecules expressed on …

The adult form of a multicellular organism is shaped by a series of morphogenetic processes
that organise the body into tissues and organs. Most of these events involve the deformation …

Morphogenesis during embryo development requires the coordination of mechanical forces
to generate the macroscopic shapes of organs. We propose a minimal theoretical model …

Understanding how molecular dynamics leads to cellular behaviours that ultimately sculpt
organs and tissues is a major challenge not only in basic developmental biology but also in …

Oogenesis is a complex developmental process that involves spatiotemporally regulated
coordination between the germline and supporting, somatic cell populations. This process …

Animal cells are thought to sense mechanical forces via the transcriptional co-activators YAP
(or YAP1) and TAZ (or WWTR1), the sole Drosophila homolog of which is named Yorkie …

The basement membrane (BM) is a specialized extracellular matrix (ECM), which underlies
or encases developing tissues. Mechanical properties of encasing BMs have been shown to …

Organs are sculpted by extracellular as well as cell-intrinsic forces, but how collective cell
dynamics are orchestrated in response to environmental cues is poorly understood. Here we …

Throughout oogenesis, Drosophila egg chambers traverse the fine line between survival
and death. After surviving the ten early and middle stages of oogenesis, egg chambers …

Epithelial structures are foundational for tissue organization in all metazoans. Sheets of
epithelial cells form lateral adhesive junctions and acquire apico-basal polarity …