[HTML][HTML] Early detection of pancreatic cancer: opportunities and challenges
Most patients with pancreatic ductal adenocarcinoma (PDAC) present with symptomatic,
surgically unresectable disease. Although the goal of early detection of PDAC is laudable …
surgically unresectable disease. Although the goal of early detection of PDAC is laudable …
LRG1: an emerging player in disease pathogenesis
The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a
key player in pathogenic ocular neovascularization almost a decade ago. Since then, an …
key player in pathogenic ocular neovascularization almost a decade ago. Since then, an …
Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers
The earlier diagnosis of cancer is one of the keys to reducing cancer deaths in the future.
Here we describe our efforts to develop a noninvasive blood test for the detection of …
Here we describe our efforts to develop a noninvasive blood test for the detection of …
Lead-time trajectory of CA19-9 as an anchor marker for pancreatic cancer early detection
JF Fahrmann, CM Schmidt, X Mao, E Irajizad, M Loftus… - Gastroenterology, 2021 - Elsevier
Background & Aims There is substantial interest in liquid biopsy approaches for cancer early
detection among subjects at risk, using multi-marker panels. CA19-9 is an established …
detection among subjects at risk, using multi-marker panels. CA19-9 is an established …
Extracellular matrices and cancer-associated fibroblasts: targets for cancer diagnosis and therapy?
I Belhabib, S Zaghdoudi, C Lac, C Bousquet, C Jean - Cancers, 2021 - mdpi.com
Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …
Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection
T Li, Y Shao, L Fu, YI Xie, L Zhu, W Sun, R Yu… - Journal of Molecular …, 2018 - Springer
To observe the diagnostic values of circular RNAs (circRNAs), their expression profiles
between gastric cancer patients' plasma and healthy controls were first assessed by …
between gastric cancer patients' plasma and healthy controls were first assessed by …
Detection of early pancreatic ductal adenocarcinoma with thrombospondin-2 and CA19-9 blood markers
J Kim, WR Bamlet, AL Oberg, KG Chaffee… - Science translational …, 2017 - science.org
Markers are needed to facilitate early detection of pancreatic ductal adenocarcinoma
(PDAC), which is often diagnosed too late for effective therapy. Starting with a PDAC cell …
(PDAC), which is often diagnosed too late for effective therapy. Starting with a PDAC cell …
Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy
Pancreatic ductal adenocarcinoma (PDAC) is usually detected late in the disease process.
Clinical workup through imaging and tissue biopsies is often complex and expensive due to …
Clinical workup through imaging and tissue biopsies is often complex and expensive due to …
Reshaping the tumor stroma for treatment of pancreatic cancer
C Vennin, KJ Murphy, JP Morton, TR Cox, M Pajic… - Gastroenterology, 2018 - Elsevier
Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between
tumor cells and the stroma to promote tumor progression. Consequently, strategies to target …
tumor cells and the stroma to promote tumor progression. Consequently, strategies to target …
Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer
S Ferguson, KS Yang, P Zelga, AS Liss… - Science …, 2022 - science.org
Tumor cell–derived extracellular vesicles (EVs) are being explored as circulating
biomarkers, but it is unclear whether bulk measurements will allow early cancer detection …
biomarkers, but it is unclear whether bulk measurements will allow early cancer detection …