Despite the abundant ongoing research efforts, cancer remains one of the most challenging
diseases to treat globally. Due to the heterogenous nature of cancer, one of the major …

The cancer stem cell (CSC) hypothesis, despite the limitations of the currently available
models and assays, has ushered in a new era of excitement in cancer research. The …

CD133 marks self-renewing cancer stem cells (CSCs) in a variety of solid tumors, and
CD133+ tumor-initiating cells are known markers of chemo-and radio-resistance in multiple …

Gliomas are the most aggressive primary brain tumors. However, no significant improvement
in survival has been achieved with the addition of temozolomide (TMZ) or radiation as initial …

Humans possess the remarkable ability to perceive color, shape, and motion, and to
differentiate between light intensities varied by over nine orders of magnitude …

To serve vision, vertebrate rod and cone photoreceptors must detect photons, convert the
light stimuli into cellular signals, and then convey the encoded information to downstream …

Nonsyndromic recessive retinal dystrophies cause severe visual impairment due to the
death of photoreceptor and retinal pigment epithelium cells. These diseases until recently …

Stem and progenitor cells are characterized by their ability to self-renew and produce
differentiated progeny. A fine balance between these processes is achieved through …

The pentaspan membrane glycoprotein CD133 marks lineage-specific cancer progenitor
cells and is associated with poor prognosis in a number of tumor types. Despite its utility as a …

Background Age-related macular degeneration (AMD) is a leading cause of blindness
among the elderly characterized by retinal pigment epithelium (RPE) degeneration with …