The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Breast cancer is the most commonly diagnosed cancer and second-leading cause of cancer
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …

Signal transducer and activator of transcription 3 (STAT3), a member of the STAT family,
discovered in the cytoplasm of almost all types of mammalian cells, plays a significant role in …

Through the study of transcriptional activation in response to interferon α (IFN-α) and
interferon γ (IFN-γ), a previously unrecognized direct signal transduction pathway to the …

▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors …

Interferon regulatory factors (IRFs) constitute a family of transcription factors that commonly
possess a novel helix-turn-helix DNA-binding motif. Following the initial identification of two …

The discovery that Src homology 2 (SH2) domains provide phosphorylation-dependent and
sequence-specific contacts for assembly of receptor signaling complexes has provided a …

▪ Abstract During the last several years, the mechanism of IFNγ-dependent signal
transduction has been the focus of intense investigation. This research has recently …

Communication between cells assumes particular importance in multicellular organisms.
The growth, migration and differentiation of cells in the embryo, and their organization into …

Acute-phase response factor (APRF) is a transcription factor that blnds to the Interfeukln-6
(IL-@-responsive elements identlfled In the promoters of various acutephase protein genes …