METHODS: The study was a multicenter, randomized, blinded, controlled, phase IIb trial
investigating the efficacy and safety of levetiracetam compared with phenobarbital as a first …

Seizures are the most common neurological disorder in newborns and are most prevalent in
the neonatal period. They are mostly caused by severe disorders of the central nervous …

Neonatal seizures are a common neurologic emergency for which therapies have not
significantly changed in decades. Improvements in diagnosis and pathophysiologic …

Introduction One of the most frequent neurological conditions in newborns is neonatal
seizures, which may indicate severe neurological dysfunction. These seizures may have …

Objective To describe the clinical characteristics, MRI findings and neurodevelopmental
outcome of infants with documented perinatal asphyxia and seizure onset within 24 hours …

Objective Few studies have evaluated the efficacy of antiseizure medications (ASMs)
according to the etiology of neonatal acute provoked seizures. We aimed to investigate the …

Introduction Neonatal seizures are the most common clinical manifestation of neurological
dysfunction in newborns, with an incidence ranging from 1 to 5‰. However, the therapeutic …

Background Padsevonil (PSL) is a rationally designed anti-seizure medication (ASM) which
has overlapping mechanisms of action with the two most common ASMs used for neonatal …

Introduction: Alexander disease (AxD) is a rare neurodegenerative condition that represents
the group of leukodystrophies. The disease is caused by GFAP mutation. Symptoms usually …

Seizures are the most common neurological disorders in newborns. Managing neonatal
seizures is challenging, especially for neurologists who are not neonatal specialists. Acute …