High mortality and morbidity rates associated with severe infections in the critically ill
continue to be a significant issue for the healthcare system. In view of the diverse and …

Linezolid has been successfully used for treatment of multidrug-resistant tuberculosis (MDR-
TB). However, dose-and duration-related toxicity limit its use. Here, our aim was to search …

Introduction: Linezolid is an oxazolidinone with potent activity against M tuberculosis, and
improves culture conversion and cure rates when added to treatment regimens for drug …

Abstract Background and Objective Quantifying exposure to drugs for personalized dose
adjustment is of critical importance in patients with tuberculosis who may be at risk of …

Therapeutic drug monitoring (TDM) is a tool used to integrate pharmacokinetic and
pharmacodynamic knowledge to optimise and personalize drug therapy. TDM is of specific …

Introduction: Oxazolidinones are synthetic antibiotics with bacteriostatic activity against
Gram-positive pathogens. Linezolid, the first marketed oxazolidinone, has shown also …

Background: Therapeutic drug monitoring is useful in the treatment of tuberculosis to assure
adequate exposure, minimize antibiotic resistance, and reduce toxicity. Salivary therapeutic …

An ultra high-performance liquid chromatographic (UHPLC) method with PDA detection was
developed and validated for the simultaneous quantification of metronidazole, meropenem …

Background In TB, therapeutic drug monitoring (TDM) is recommended for linezolid;
however, implementation is challenging in endemic settings. Non-invasive saliva sampling …

The spread of tuberculosis (TB), especially multidrug-resistant TB and extensively drug-
resistant TB, has strongly motivated the research and development of new anti-TB drugs …