Epidemiology of uterine fibroids: from menarche to menopause

LA Wise, SK Laughlin-Tommaso - Clinical obstetrics and …, 2016 - journals.lww.com
Uterine leiomyomata (UL) have a substantial impact on women's health, but relatively few
studies have identified opportunities for primary prevention of these neoplasms. Most …

A review of the carcinogenic potential of bisphenol A

DD Seachrist, KW Bonk, SM Ho, GS Prins… - Reproductive …, 2016 - Elsevier
The estrogenic properties of bisphenol A (BPA), a ubiquitous synthetic monomer that can
leach into the food and water supply, have prompted considerable research into exposure …

New directions in the epidemiology of uterine fibroids

SK Laughlin, JC Schroeder… - Seminars in reproductive …, 2010 - thieme-connect.com
Although uterine leiomyomata (fibroids) have been the leading indication for hysterectomy in
the United States for decades, the epidemiological data on fibroid prevalence and risk …

[HTML][HTML] Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response

JG Bromer, Y Zhou, MB Taylor, L Doherty… - The FASEB …, 2010 - ncbi.nlm.nih.gov
Bisphenol-A (BPA) is a nonsteroidal estrogen that is ubiquitous in the environment. The
homeobox gene Hoxa10 controls uterine organogenesis, and its expression is affected by in …

Racial and ethnic disparities in benign gynecologic conditions and associated surgeries

VL Jacoby, VY Fujimoto, LC Giudice… - American journal of …, 2010 - Elsevier
Common gynecologic conditions and surgeries may vary significantly by race or ethnicity.
Uterine fibroid tumors are more prevalent in black women, and black women may have …

The mechanism and function of epigenetics in uterine leiomyoma development

Q Yang, A Mas, MP Diamond… - Reproductive …, 2016 - journals.sagepub.com
Uterine leiomyomas, also known as uterine fibroids, are the most common pelvic tumors,
occurring in nearly 70% of all reproductive-aged women and are the leading indication for …

Developmental reprogramming of cancer susceptibility

CL Walker, S Ho - Nature Reviews Cancer, 2012 - nature.com
Gene–environment interactions have been traditionally understood to promote the
acquisition of mutations that drive multistage carcinogenesis, and, in the case of inherited …

Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis

KL Greathouse, T Bredfeldt, JI Everitt, K Lin… - Molecular Cancer …, 2012 - AACR
Environmental exposures during sensitive windows of development can reprogram normal
physiologic responses and alter disease susceptibility later in life in a process known as …

Role of stem cells in human uterine leiomyoma growth

M Ono, W Qiang, VA Serna, P Yin, JS Coon, A Navarro… - PloS one, 2012 - journals.plos.org
Background Uterine leiomyoma is the most common benign tumor in reproductive-age
women. Each leiomyoma is thought to be a benign monoclonal tumor arising from a single …

Transgenerational neuroendocrine disruption of reproduction

DM Walker, AC Gore - Nature Reviews Endocrinology, 2011 - nature.com
Exposure to endocrine disrupting chemicals (EDCs) is associated with dysfunctions of
metabolism, energy balance, thyroid function and reproduction, and an increased risk of …