Overcoming immune evasion in melanoma
Melanoma is the most aggressive and dangerous form of skin cancer that develops from
transformed melanocytes. It is crucial to identify melanoma at its early stages, in situ, as it is …
transformed melanocytes. It is crucial to identify melanoma at its early stages, in situ, as it is …
G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers
N Arang, JS Gutkind - FEBS letters, 2020 - Wiley Online Library
G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …
Exome sequencing identifies GRIN2A as frequently mutated in melanoma
The incidence of melanoma is increasing more than any other cancer, and knowledge of its
genetic alterations is limited. To systematically analyze such alterations, we performed …
genetic alterations is limited. To systematically analyze such alterations, we performed …
Decoding melanoma development and progression: identification of therapeutic vulnerabilities
Melanoma, a cancer of the skin, arises from transformed melanocytes. Melanoma has the
highest mutational burden of any cancer partially attributed to UV induced DNA damage …
highest mutational burden of any cancer partially attributed to UV induced DNA damage …
[HTML][HTML] Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity
MD Sharma, R Pacholczyk, H Shi, ZJ Berrong… - Immunity, 2021 - cell.com
Monocytic-lineage inflammatory Ly6c+ CD103+ dendritic cells (DCs) promote antitumor
immunity, but these DCs are infrequent in tumors, even upon chemotherapy. Here, we …
immunity, but these DCs are infrequent in tumors, even upon chemotherapy. Here, we …
Glutamate and its receptors in cancer
A Stepulak, R Rola, K Polberg… - Journal of neural …, 2014 - Springer
Glutamate, a nonessential amino acid, is a major bioenergetic substrate for proliferating
normal and neoplastic cells on one hand and an excitatory neurotransmitter that is actively …
normal and neoplastic cells on one hand and an excitatory neurotransmitter that is actively …
Exciting times beyond the brain: metabotropic glutamate receptors in peripheral and non-neural tissues
Metabotropic glutamate (mGlu) receptors are G-protein-coupled receptors expressed
primarily on neurons and glial cells, where they are located in the proximity of the synaptic …
primarily on neurons and glial cells, where they are located in the proximity of the synaptic …
[HTML][HTML] GRM1 gene fusions as an alternative molecular driver in blue nevi and related melanomas
T Kervarrec, GL Bello, D Pissaloux, F Tirode… - Modern Pathology, 2023 - Elsevier
Activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4 genes are regarded as the
main oncogenic drivers of blue nevi (BN) and blue malignant melanocytic tumors. Here we …
main oncogenic drivers of blue nevi (BN) and blue malignant melanocytic tumors. Here we …
Metabotropic glutamate receptors in cancer
Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic
signaling. However, accumulating evidence suggests roles of mGluRs in human …
signaling. However, accumulating evidence suggests roles of mGluRs in human …
Serum glutamate levels correlate with Gleason score and glutamate blockade decreases proliferation, migration, and invasion and induces apoptosis in prostate …
S Koochekpour, S Majumdar, G Azabdaftari… - Clinical cancer …, 2012 - AACR
Purpose: During glutaminolysis, glutamine is catabolized to glutamate and incorporated into
citric acid cycle and lipogenesis. Serum glutamate levels were measured in patients with …
citric acid cycle and lipogenesis. Serum glutamate levels were measured in patients with …