Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular
processes. Deregulation of FGFR signalling is observed in a subset of many cancers …

Over the past decade, covalent kinase inhibitors (CKI) have seen a resurgence in drug
discovery. Covalency affords a unique set of advantages as well as challenges relative to …

Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and
represents the major therapeutic target for treating metastatic prostate cancer (mPC) …

Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases
expressed on the cell membrane that play crucial roles in both developmental and adult …

Tumor-derived cell lines have served as vital models to advance our understanding of
oncogene function and therapeutic responses. Although substantial effort has been made to …

Chronic kidney disease (CKD) is a worldwide public health threat that increases risk of
death due to cardiovascular complications, including left ventricular hypertrophy (LVH) …

Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to
cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …

Circulating tumor cells (CTCs) are present at low concentrations in the peripheral blood of
patients with solid tumors. It has been proposed that the isolation, ex vivo culture, and …

The mechanism by which pharmacologic administration of the hormone FGF21 increases
energy expenditure to cause weight loss in obese animals is unknown. Here we report that …

Inhibition of tumor angiogenesis by blockading the vascular endothelial growth factor
(VEGF) signaling pathway is a promising therapeutic strategy for thyroid cancer. Lenvatinib …