Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …

Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …

Elucidating the cellular organization of the cerebral cortex is critical for understanding brain
structure and function. Using large-scale single-nucleus RNA sequencing and spatial …

The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

The large number of ion channels found in all nervous systems poses fundamental
questions concerning how the characteristic intrinsic properties of single neurons are …

Classification and characterization of neuronal types are critical for understanding their
function and dysfunction. Neuronal classification schemes typically rely on measurements of …

One of the most captivating questions in neuroscience revolves around the brain's ability to
efficiently and durably capture and store information. It must process continuous input from …

Massive single-cell profiling efforts have accelerated our discovery of the cellular
composition of the human body while at the same time raising the need to formalize this new …