Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it
secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As …

A promising approach for treating type 2 diabetes mellitus (T2DM) is to target the
Peroxisome Proliferator-Activated Receptor γ (PPARγ) transcription factor, which regulates …

Emerging evidence points to the intertwining framework of inflammation and oxidative stress
in various ailments. We speculate on the potential impact of the magic shotgun approach in …

Fragment merging approach was applied for the design of thiazole/thiazolidinone clubbed
pyrazoline derivatives 5a-e, 6a-c, 7 and 10a-d as dual COX-2 and 5-LOX inhibitors …

In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …

Cancer is a multifactorial disorder involving multiplicity of interrelated signaling pathways
and molecular targets. To that end, a multi-target design strategy was adopted to develop …

Based on the observed pharmacophoric structural features for the reported dual COX/15-
LOX inhibitors and inspired by the abundance of COX/LOX inhibitory activities reported for …

Abstract Dual cyclooxygenase 2/15-lipoxygenase inhibitors constitute a valuable alternative
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …

Abstract Multi-target EGFR, HER2, VEGFR-2 and PDGFR is an improved strategy for the
treatment of solid tumors. This work deals with synthesis of an array of new 6-benzoyl …

Structural modifications of the antibacterial drug nitrofurantoin were envisioned, employing
drug repurposing and biology-oriented drug synthesis, to serve as possible anticancer …