Posttranslational modification of proteins is important for signal transduction, and hence
significant effort has gone toward understanding how posttranslational modification …

Sensing and responding to the environment are two essential functions that all biological
organisms need to master for survival and successful reproduction. Developmental …

Mathematical modelling has become an established tool for studying the dynamics of
biological systems. Current applications range from building models that reproduce …

Many dynamical systems arising in biology and other areas exhibit multistationarity (two or
more positive steady states with the same conserved quantities). Although deciding …

Chemical reaction systems are dynamical systems that arise in chemical engineering and
systems biology. In this work, we consider the question of whether the minimal (in a precise …

Switch-like responses arising from bistability have been linked to cell signaling processes
and memory. Revealing the shape and properties of the set of parameters that lead to …

Mathematical models are increasingly being used to understand complex biochemical
systems, to analyse experimental data and make predictions about unobserved quantities …

We introduce a general framework for biological systems, called MESSI systems, that
describe Modifications of type Enzyme-Substrate or Swap with Intermediates, and we prove …

In systems and synthetic biology, much research has focused on the behavior and design of
single pathways, while, more recently, experimental efforts have focused on how cross-talk …

Dual phosphorylation of proteins is a principal component of intracellular signalling.
Bistability is considered an important property of such systems and its origin is not yet …