Protein aggregation is classically considered the main cause of neuronal death in
neurodegenerative diseases (NDDs). However, increasing evidence suggests that alteration …

Autoimmune diseases are a diverse set of conditions defined by organ damage due to
abnormal innate and acquired immune system responses. The pathophysiology of …

Multiple sclerosis (MS) is a degenerative condition characterized by axonal damage and
demyelination induced by autoreactive immune cells that occur in the Central Nervous …

T-lymphocytes (T cells) play a major role in adaptive immunity and current immune
checkpoint inhibitor-based cancer treatments. The regulation of their function is complex …

T helper (Th) 17 cells are one of the most important T cell subsets in a number of
autoimmune and chronic inflammatory diseases. During infections, Th17 cells appear to …

CD4+ T cells differentiate towards different subpopulations through the regulation of lineage-
specific cytokines and transcription factors, which flexibly respond to various immune …

Multiple sclerosis (MS) is a chronic neuroinflammatory disease that causes severe
neurological dysfunction leading to disabilities in patients. The prevalence of the disease …

Slow-burning inflammation at the lesion rim is connected to the expansion of chronic
multiple sclerosis (MS) lesions. However, the underlying processes causing expansion are …

Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous
system, is one of the most common neurodegenerative diseases worldwide. MS results in …

Objective. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system
characterized by chronic inflammation and demyelination. This study is aimed at identifying …