Antibody–drug conjugates: a comprehensive review
Antibody–drug conjugates (ADC) are one of the fastest growing anticancer drugs. This
approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that …
approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that …
The neonatal Fc receptor (FcRn): a misnomer?
M Pyzik, KMK Sand, JJ Hubbard, JT Andersen… - Frontiers in …, 2019 - frontiersin.org
Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …
(IgG) is the most common type of antibody found in circulation and extracellular fluids …
Emerging role of the spleen in the pharmacokinetics of monoclonal antibodies, nanoparticles and exosomes
M Cataldi, C Vigliotti, T Mosca, MR Cammarota… - International journal of …, 2017 - mdpi.com
After being absorbed, drugs distribute in the body in part to reach target tissues, in part to be
disposed in tissues where they do not exert clinically-relevant effects. Therapeutically …
disposed in tissues where they do not exert clinically-relevant effects. Therapeutically …
Antibody conjugates-recent advances and future innovations
Monoclonal antibodies have evolved from research tools to powerful therapeutics in the past
30 years. Clinical success rates of antibodies have exceeded expectations, resulting in …
30 years. Clinical success rates of antibodies have exceeded expectations, resulting in …
Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development
abstract Protein therapeutics represent a diverse array of biologics including antibodies,
fusion proteins, and therapeutic replacement enzymes. Since their inception, they have …
fusion proteins, and therapeutic replacement enzymes. Since their inception, they have …
GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys
SC Lu, M Chen, L Atangan, EA Killion… - Cell Reports …, 2021 - cell.com
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
regulate glucose and energy homeostasis. Targeting both pathways with GIP receptor …
regulate glucose and energy homeostasis. Targeting both pathways with GIP receptor …
Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
Abstract Background Transferrin receptor (TfR1) mediated enhanced brain delivery of
antibodies have been studied extensively in preclinical settings. However, the brain …
antibodies have been studied extensively in preclinical settings. However, the brain …
Mechanisms influencing the pharmacokinetics and disposition of monoclonal antibodies and peptides
A Datta-Mannan - Drug Metabolism and Disposition, 2019 - ASPET
Monoclonal antibodies (mAbs) and peptides are an important class of therapeutic modalities
that have brought improved health outcomes in areas with limited therapeutic optionality …
that have brought improved health outcomes in areas with limited therapeutic optionality …
A comprehensive review of the neonatal Fc receptor and its application in drug delivery
Advances in the understanding of neonatal Fc receptor (FcRn) biology and function have
demonstrated that this receptor, primarily identified for the transfer of passive immunity from …
demonstrated that this receptor, primarily identified for the transfer of passive immunity from …
Understanding inter-individual variability in monoclonal antibody disposition
VA Thomas, JP Balthasar - Antibodies, 2019 - mdpi.com
Monoclonal antibodies (mAbs) are currently the largest and most dominant class of
therapeutic proteins. Inter-individual variability has been observed for several mAbs; …
therapeutic proteins. Inter-individual variability has been observed for several mAbs; …