Objective The risk-benefit profile of antidepressant medications in bipolar disorder is
controversial. When conclusive evidence is lacking, expert consensus can guide treatment …

Objectives. These guidelines are based on a first edition that was published in 2004, and
have been edited and updated with the available scientific evidence up to October 2012 …

Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Beaulieu S, Alda M, O'Donovan C,
MacQueen G, McIntyre RS, Sharma V, Ravindran A, Young LT, Milev R, Bond DJ, Frey BN …

Context Major depressive disorder, the most common psychiatric illness, is often chronic and
a major cause of disability. Many patients with major depressive episodes who have an …

Objective We discuss the rationale behind staging systems described specifically for bipolar
disorders. Current applications, future directions and research gaps in clinical staging …

The proper place and the optimal use of antidepressants in treating bipolar depression
continues to be an area of great interest and greater controversy with passionate opinions …

Background: The current paper includes a systematic search of the literature, a detailed
presentation of the results, and a grading of treatment options in terms of efficacy and …

Objectives Rapid cycling is a common and disabling phenomenon in individuals with bipolar
disorders. In the absence of a recent literature examination, this systematic review and meta …

There is increasing awareness that, in some cases, long-term use of antidepressant drugs
(AD) may enhance the biochemical vulnerability to depression and worsen its long-term …

The current statement is a systematic review of the available data concerning the efficacy of
medication treatment of bipolar disorder (BP). A systematic MEDLINE search was made …