Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …

Abstract Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven
effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the …

Recurrent somatic mutations in histone 3 (H3) variants (termed 'oncohistones') have been
identified in high-grade gliomas (HGGs) in children and young adults and induce …

Mammalian SWI/SNF chromatin remodeling complexes move and evict nucleosomes at
gene promoters and enhancers to modulate DNA access. Although SWI/SNF subunits are …

Diffuse midline gliomas (DMGs) including diffuse intrinsic pontine gliomas (DIPGs) bearing
lysine-to-methionine mutations in histone H3 at lysine 27 (H3K27M) are lethal childhood …

H3 K27‐altered diffuse midline glioma is a highly lethal pediatric‐type tumor without
efficacious treatments. Recent findings have highlighted the heterogeneity among diffuse …

Pediatric brain tumors comprise a diverse set of diseases.(Epi) genomic analyses have
provided insights into the biology of these tumors, stratifying them into distinct subtypes with …

In the past two decades, technological advances have brought unprecedented insights into
the paediatric cancer genome revealing characteristics distinct from those of adult cancer …

Recurrent, clonal somatic mutations in histone H3 are molecular hallmarks that distinguish
the genetic mechanisms underlying pediatric and adult high-grade glioma (HGG), define …

Background & Aims The dismal prognosis of pancreatic ductal adenocarcinoma (PDAC) is
linked to the presence of pancreatic cancer stem-like cells (CSCs) that respond poorly to …