Abstract Insulin-Like Growth Factor 1 (IGF-1) is a phylogenetically ancient neurotrophic
hormone with crucial roles to play in CNS development and maturation. Recently, IGF-1 has …

Although synaptic loss is thought to be core to the pathophysiology of schizophrenia, the
nature, consistency and magnitude of synaptic protein and mRNA changes has not been …

The functions of synapsins were examined by characterizing the phenotype of mice in which
all three synapsin genes were knocked out. Although these triple knock-out mice were …

Neural tissue has limited capacity for intrinsic repair after injury, and the identification of
alternate sources of neuronal stem cells has broad clinical potential. Preliminary studies …

Formation of β-linked Asp-Xaa peptide bonds–isoaspartyl (isoAsp) sites–arise in proteins
via succinimide− linked deamidation of asparagine or dehydration of aspartate, reactions …

Understanding the relationship between brain and behavior is the fundamental challenge in
neuroscience. We focus on chemosensation and chemosensory learning in larval …

Synapsins serve as flagships among the presynaptic proteins due to their abundance on
synaptic vesicles and contribution to synaptic communication. Several studies have …

Reactive oxygen species (ROS) modulate intracellular signaling but are also responsible for
neuronal damage in pathological states. Microglia, the resident CNS macrophages, are …

We have investigated the trafficking of two endogenous axonal membrane proteins, VAMP2
and NgCAM, in order to elucidate the cellular events that underlie their polarization. We …

The last 30 years have witnessed tremendous progress in elucidating the basic mechanisms
underlying a simple form of olfactory learning and memory in Drosophila. The application of …