Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

Chronic autoimmune diseases, and in particular Systemic Lupus Erythematosus (SLE), are
endowed with a long‐standing autoreactive B‐cell compartment that is presumed to …

Summary Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …

The unique differentiation of IgE cells suggests unconventional mechanisms of IgE memory.
IgE germinal centre cells are transient, most IgE cells are plasma cells, and high affinity IgE …

Human B cells could be divided into four classical subsets based on CD27 and
immunoglobulin (Ig) D expression. Distinct from the other three well-studied subsets, CD27 …

Systemic lupus erythematosus (SLE) is an autoimmune illness marked by the loss of
immune tolerance and the production of autoantibodies against nucleic acids and other …

Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding
domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B …

B cells expressing the transcription factor T-bet are found to have a protective role in viral
infections, but are also considered major players in the onset of different types of …

Recent clinical trials have shown promising results for the next-generation Bruton's tyrosine
kinase (BTK) inhibitor evobrutinib in the treatment of multiple sclerosis (MS). BTK has a …

Epstein-Barr virus (EBV) maintains a lifelong latent infection within a subset of its host's
memory B cells, while lytic EBV replication takes place in plasma cells and differentiated …