The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …

The introduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the
human population represents a tremendous medical and economic crisis. Innate immunity …

Antiviral signalling, which can be activated in host cells upon virus infection, restricts virus
replication and communicates infection status to neighbouring cells. The antiviral response …

Traditionally, the viral replication cycle is envisioned as a single, well-defined loop with four
major steps: attachment and entry into a target cell, replication of the viral genome …

Type I interferon (IFN) is a key driver of immunity to infections and cancer. Plasmacytoid
dendritic cells (pDCs) are uniquely equipped to produce large quantities of type I IFN but the …

Viral infection is usually studied at the population level by averaging over millions of cells.
However, infection at the single-cell level is highly heterogeneous, with most infected cells …

Pathogens comprise a diverse set of immunostimulatory molecules that activate the innate
immune system during infection. The immune system recognizes distinct combinations of …

RNA viruses are among the most prevalent pathogens and are a major burden on society.
Although RNA viruses have been studied extensively, little is known about the processes …

Type I Interferon (IFN-I) responses were first recognized for their role in antiviral immunity,
but it is now widely appreciated that IFN-Is have many immunomodulatory functions …

Cells receive time-varying signals from the environment and generate functional responses
by secreting their own signaling molecules. Characterizing dynamic input-output …