Postoperative cognitive dysfunction (POCD) is a common disorder following surgery, which
seriously threatens the quality of patients' life, especially the older people. Accumulating …

The population of aged individuals is increasing worldwide and this has significant health
and socio-economic implications. Clinical and experimental studies on aging have …

Aging is the greatest risk factor for most diseases including cancer, cardiovascular disorders,
and neurodegenerative disease. There is emerging evidence that interventions that improve …

There has been, and continues to be, a dramatic shift in the human population towards older
ages necessitating biomedical research aimed at better understanding the basic biology of …

Neurodegenerative disorders are spreading worldwide and are one of the greatest threats to
public health. There is currently no adequate therapy for these disorders, and therefore there …

The last few decades of longevity research have been very exciting. We now know that
longevity and healthspan can be manipulated across species, from unicellular eukaryotes to …

Adipose tissue expansion has been associated with system‐wide metabolic dysfunction and
increased vulnerability to diabetes, cancer, and cardiovascular disease. A reduction in …

Nicotinamide adenine dinucleotide (NAD+) is an essential molecule involved in various
metabolic reactions, acting as an electron donor in the electron transport chain and as a co …

GSK3β is a serine threonine kinase implicated in the progression of Alzheimer's disease.
Although the role of GSK3β in growth and pathology has been extensively studied, little is …

Exosomes represent a strategy for optimizing the adeno-associated virus (AAV) toward the
development of novel therapeutic options for neurodegenerative disorders. However, in vivo …