Prognostic significance of tumor-infiltrating B cells and plasma cells in human cancer

MCA Wouters, BH Nelson - Clinical Cancer Research, 2018 - AACR
There is abundant evidence that tumor-infiltrating CD8+ T cells contribute positively to
antitumor immunity; however, the role of tumor-infiltrating B cells (TIL-B) and plasma cells …

The prognostic role of tumor infiltrating T-lymphocytes in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis

EJ de Ruiter, ML Ooft, LA Devriese… - Oncoimmunology, 2017 - Taylor & Francis
Background–The presence of tumor-infiltrating lymphocytes (TILs) in the tumor
microenvironment is associated with an improved prognosis and a better response to …

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

J Griss, W Bauer, C Wagner, M Simon, M Chen… - Nature …, 2019 - nature.com
Tumor associated inflammation predicts response to immune checkpoint blockade in human
melanoma. Current theories on regulation of inflammation center on anti-tumor T cell …

Exploiting the curative potential of adoptive T‐cell therapy for cancer

CS Hinrichs, SA Rosenberg - Immunological reviews, 2014 - Wiley Online Library
Adoptive T‐cell therapy (ACT) is a potent and flexible cancer treatment modality that can
induce complete, durable regression of certain human malignancies. Long‐term follow‐up …

Tumor infiltrating lymphocytes and survival in patients with head and neck squamous cell carcinoma

N Nguyen, E Bellile, D Thomas, J McHugh… - Head & …, 2016 - Wiley Online Library
Background Because immune responses within the tumor microenvironment are important
predictors of tumor biology, correlations of types of tumor infiltrating lymphocytes (TILs) with …

The secret ally: immunostimulation by anticancer drugs

L Galluzzi, L Senovilla, L Zitvogel… - Nature reviews Drug …, 2012 - nature.com
It has recently become clear that the tumour microenvironment, and in particular the immune
system, has a crucial role in modulating tumour progression and response to therapy …

The prognostic value of FoxP3+ tumor-infiltrating lymphocytes in cancer: a critical review of the literature

RJ Deleeuw, SE Kost, JA Kakal, BH Nelson - Clinical cancer research, 2012 - AACR
Abstract CD8+ tumor-infiltrating lymphocytes (TIL) are associated with survival in a variety of
cancers. A second subpopulation of TIL, defined by forkhead box protein P3 (FoxP3) …

Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer

P Balermpas, Y Michel, J Wagenblast, O Seitz… - British journal of …, 2014 - nature.com
Background: We aimed to investigate the prognostic value of tumour-infiltrating
lymphocytes'(TILs) expression in pretreatment specimens from patients with head and neck …

Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity

C Jochems, J Schlom - Experimental biology and medicine, 2011 - journals.sagepub.com
Numerous studies have now documented a link between the immune infiltrate in several
human carcinoma types and prognosis and response to therapy. The most comprehensive …

CD 8+ tumour‐infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A …

P Balermpas, F Rödel, C Rödel… - … journal of cancer, 2016 - Wiley Online Library
We examined the prognostic value of tumour‐infiltrating lymphocytes (TILs) in patients with
squamous cell carcinoma of the head and neck (SCCHN) after surgery and postoperative …