Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the
mammalian host macrophages, involving several environmental changes. The parasite …

BACKGROUND: Trypanosomatids are early-diverging eukaryotes devoid of the major
disulfide reductases–glutathione reductase and thioredoxin reductase–that control thiol …

Studies of Leishmania donovani have shown that both ornithine decarboxylase and
spermidine synthase, two enzymes of the polyamine biosynthetic pathway, are critical for …

Leishmania are parasitic protists that cause a spectrum of diseases in humans characterized
by the formation of granulomatous lesions in the skin or other tissues, such as liver and …

Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans worldwide. Because a vaccine is not available and the currently small number of …

In trypanosomatids, polyamine and trypanothione pathways can be considered as a whole
unique metabolism, where most enzymes are essential for parasitic survival and infectivity …

Significance: Parasitic infections continue to be a major problem for global human health.
Vaccines are practically not available and chemotherapy is highly unsatisfactory. One …

Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans and domestic animals worldwide. The need for new therapeutic strategies is urgent …

Despite decades of research devoted to finding a vaccine against leishmaniasis, we are still
lacking a safe and effective vaccine for humans. Given this scenario, the search for a new …

Arginase from parasitic protozoa belonging to the genus Leishmania is a potential drug
target for the treatment of leishmaniasis because this binuclear manganese metalloenzyme …