Neuroinflammatory processes are a central feature of Alzheimer's disease (AD) in which
microglia are over-activated, resulting in the increased production of pro-inflammatory …

Alzheimer's disease (AD) is a scourge of longevity that will drain enormous resources from
public health budgets in the future. Currently, there is no diagnostic biomarker and/or …

The blood–brain barrier (BBB) is a tightly regulated barrier in the central nervous system.
Though the BBB is thought to be intact during neurodegenerative diseases such as …

Anesthetics have been reported to promote Alzheimer's disease (AD) neuropathogenesis by
inducing β-amyloid protein accumulation and apoptosis. Neuroinflammation is associated …

During the past few years, an increasing set of evidence has supported the major role of
deregulation of the interaction patterns between glial cells and neurons in the pathway …

The idea that alterations in the brain immunomodulation are critical for Alzheimer's disease
(AD) pathogenesis provides the most integrative view on this cognitive disorder, considering …

Substantial basic science and clinical evidence suggests that excess tumor necrosis factor-
alpha (TNF-alpha) is centrally involved in the pathogenesis of Alzheimer's disease. In …

Highlights•TNFα biosynthesis, TNF receptors, and signaling.•Neurotoxicity of TNFα in the
brain.•TNFα receptor signaling-related neuron death and neuroprotection.•TNF receptors …

Biomarkers are increasingly employed in empirical studies of human populations to
understand physiological processes that change with age, diseases whose onset appears …

It has been suggested that molecular pathological mechanisms responsible for periodontitis
can be linked with biochemical alterations in neurodegenerative disorders. Hypothetically …