Molecular imaging is the visualization, characterization, and measurement of biological
processes at the molecular and cellular levels in humans and other living systems …

The molecules known as bis (thiosemicarbazones) derived from 1, 2-diones can act as
tetradentate ligands for Cu (II), forming stable, neutral complexes. As a family, these …

Neutral and cationic copper bis (thiosemicarbazone) complexes bearing methyl, phenyl, and
hydrogen, on the diketo-backbone of the ligand have been synthesized. All of them were …

A series of eight bis (thiosemicarbazone) ligands and 16 of their respective copper (II) and
zinc (II) complexes containing a combination of hydrogen, methyl, pyridyl, phenyl, and/or …

Cognitive decline in Alzheimer's disease (AD) involves pathological accumulation of
synaptotoxic amyloid-β (Aβ) oligomers and hyperphosphorylated tau. Because recent …

Superoxide dismutases (SODs) are essential antioxidant enzymes that prevent massive
superoxide radical production and thus protect cells from damage induced by free radicals …

Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic
lateral sclerosis (ALS) in humans and an expression level-dependent phenotype in …

Essential metals, such as iron and copper, play a critical role in a plethora of cellular
processes including cell growth and proliferation. However, concomitantly, excess of these …

Highlights•Copper radionuclides for in vivo imaging of biological functions of copper
ions.•Copper-64 has suitable nuclear properties for cancer theranostics.•Radioactive copper …

A series of hybrid ligands (H 2 L 1–H 2 L 3) derived from 4-methyl-3-thiosemicarbazide and
hydrazinecarbothioic acid O-alkyl esters were synthesized and characterized by NMR. The …