X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

Proper expression of genes requires communication with their regulatory elements that can
be located elsewhere along the chromosome. The physics of chromatin fibers imposes a …

The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …

Mammalian genomes are viewed as functional organizations that orchestrate spatial and
temporal gene regulation. CTCF, the most characterized insulator-binding protein, has been …

Although genomes are defined by their sequence, the linear arrangement of nucleotides is
only their most basic feature. A fundamental property of genomes is their topological …

To accommodate genomes in the limited space of the cell nucleus and ensure the correct
execution of gene expression programs, genomes are packaged in complex fashion in the …

In somatic nuclei of female therian mammals, the two X chromosomes display very different
chromatin states: One X is typically euchromatic and transcriptionally active, and the other is …

DNA and histone methylation are linked and subjected to mitotic inheritance in mammals.
Yet how methylation is propagated and maintained between successive cell divisions is not …

X-chromosome inactivation (XCI) ensures dosage compensation in mammals and is a
paradigm for allele-specific gene expression on a chromosome-wide scale. Important …

The development of genetic sex determination and cytologically distinct sex chromosomes
leads to the potential problem of gene dosage imbalances between autosomes and sex …