Most cardiovascular researchers are familiar with intermediate-conductance KCa3. 1 and
small-conductance KCa2. 3 channels because of their contribution to endothelium-derived …

The pathophysiology of atrial fibrillation (AF) is broad, with components related to the unique
and diverse cellular electrophysiology of atrial myocytes, structural complexity, and …

Central serous chorioretinopathy (CSCR) is a vision-threatening eye disease with no
validated treatment and unknown pathogeny. In CSCR, dilation and leakage of choroid …

In search of more efficacious and safe pharmacological treatments for atrial fibrillation (AF),
atria-selective antiarrhythmic agents have been promoted that target ion channels …

Apamin is often cited as one of the few substances selectively acting on small-conductance
Ca2+-activated potassium channels (KCa2). However, published pharmacological and …

Abstract Aims Small conductance Ca2+-activated K+ channels (KCa2 or SK channels) have
been reported in excitable cells, where they aid in integrating changes in intracellular Ca2+ …

BACKGROUND: Small conductance calcium activated potassium (SKCa) channels are
voltage insensitive and are activated by intracellular calcium. Genome-wide association …

We tested if small conductance, Ca2+‐sensitive K+ channels (SKCa) precondition hearts
against ischemia reperfusion (IR) injury by improving mitochondrial (m) bioenergetics, if O2 …

The role of IKCa in cardiac repolarization remains controversial and varies across species.
The relevance of the current as a therapeutic target is therefore undefined. We examined the …

This short review discusses pharmacological modulation of the opening/closing properties
(gating) of small-and intermediate-conductance Ca2+-activated K+ channels (KCa2 and …