Fumarate hydratase (FH) is an enzyme of the Tricarboxylic Acid (TCA) cycle whose
mutations lead to hereditary and sporadic forms of cancer. Although more than twenty years …

The study of cancer metabolism has evolved vastly beyond the remit of tumour proliferation
and survival with the identification of the role of 'oncometabolites' in tumorigenesis. Simply …

Cancer is now considered a multifactorial disorder with different aetiologies and outcomes.
Yet, all cancers share some common molecular features. Among these, the reprogramming …

Background Emerging evidence indicates the pivotal involvement of circular RNAs
(circRNAs) in cancer initiation and progression. Understanding the functions and underlying …

Abl1 kinase has important biological roles. The Bcr-Abl1 fusion protein creates undesired
kinase activity and is pathogenic in 95% of chronic myeloid leukemia (CML) and 30% of …

Protein tyrosine phosphatases (PTPs), which are ubiquitously expressed in hematopoietic
and non-hematopoietic cells, are critical for regulating cell proliferation as well as …

Advances in immunotherapy have brought significant therapeutic benefits to many cancer
patients. Nonetheless, many cancer types are refractory to current immunotherapeutic …

Hepatology Publish Ahead of Print DOI:10.1097/HEP.0000000000001133 Page 1 The de-sulfinylation
enzyme sulfiredoxin-1 attenuates hepatic stellate cell activation and liver fibrosis by …

Background: Renal cell carcinoma (RCC) is a common urological cancer, and its risk
correlates with environmental factors such as obesity, smoking and hypertension. Microarray …

Protein tyrosine phosphatase non-receptor type 12 (PTPN12) is abnormally expressed in
many human cancers. However, its role in hepatocellular carcinoma (HCC) is indeterminate …