Alzheimer's disease (AD) was used to describe pre-senile dementia to differentiate it from
senile dementia, which develops in the adult age group of more than 65 years. AD is …

Nearly 30% of adults 40 years and older in the United States are on a statin. Their
widespread use heightens the importance of careful consideration of their varied effects on …

Hypercholesterolaemia is a risk factor for the development of atherosclerotic disease.
Atorvastatin lowers plasma low-density lipoprotein (LDL) cholesterol levels by inhibition of …

The beneficial effects of statins are assumed to result from their ability to reduce cholesterol
biosynthesis. However, because mevalonic acid is the precursor not only of cholesterol, but …

ABSTRACT BACKGROUND In 2012, the United States Food and Drug Administration (FDA)
issued a warning regarding potential adverse effects of HMG-CoA reductase inhibitors …

Multiple sclerosis (MS) is a chronic progressive disabling disease of the central nervous
system (CNS) characterized by demyelination and neuronal injury. Dyslipidemia is observed …

Increased atherosclerosis risk in hyperlipidemic patients may be a result of the enhanced
oxidizability of their plasma lipoproteins. We have previously shown that …

Emerging data suggest that the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)
reductase inhibitors (statins) offer important benefits for the large population of individuals at …

Background—The role of statins in the prevention of contrast-induced acute kidney injury
(CIAKI) is controversial. Methods and Results—First, we investigated the in vivo effects of …

Rationale: Observational studies link statin therapy with improved outcomes in patients with
severe sepsis. Objectives: To test whether atorvastatin therapy affects biologic and clinical …