The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …

Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin,
HMGB1 is now known to regulate diverse biological processes depending on its subcellular …

Tumor metastases are considered the leading cause of cancer-associated deaths. While
clinically applied drugs have demonstrated to efficiently remove the primary tumor …

Phototherapy such as photothermal therapy and photodynamic therapy in cancer treatment
has been developed quickly over the past few years for its noninvasive nature and high …

The past decade has witnessed major breakthroughs in cancer immunotherapy. This
development has been largely motivated by cancer cell evasion of immunological control …

An ideal cancer treatment should not only destroy primary tumors but also improve the
immunogenicity of the tumor microenvironment to achieve a satisfactory anti‐tumor immune …

Background Immunotherapy represents the future of clinical cancer treatment. The type of
cancer cell death determines the antitumor immune response and thereby contributes to the …

Targeting ferroptosis, which provokes lipid peroxidation in cancer cells, presents potentially
new avenues for anticancer therapy. Recent studies have begun to explore how immune …

Calreticulin (CALR) is an endoplasmic reticulum (ER)-resident protein involved in a
spectrum of cellular processes. In healthy cells, CALR operates as a chaperone and Ca2+ …

A hypoxic and acidic tumor microenvironment (TME) plays a significant role in cancer
development through complex cellular signaling networks, and it is thus challenging to …