Viruses have long been considered to be the most promising tools for human gene therapy.
However, the initial enthusiasm for the use of viruses has been tarnished in the light of …

The mariner elements belong to the ITm superfamily of cut‐and‐paste DNA‐transposons.
The acronym is derived from the IS630, Tc1, and mariner elements, which represent three …

The emergence of new genes and functions is of central importance to the evolution of
species. The contribution of various types of duplications to genetic innovation has been …

A key step in cut-and-paste DNA transposition is the pairing of transposon ends before the
element is excised and inserted at a new site in its host genome. Crystallographic analyses …

DNA transposons are mobile DNA elements that can move from one DNA molecule to
another and thereby deliver genetic information into human chromosomes in order to confer …

How do DNA transposons live in harmony with their hosts? Bacteria provide the only
documented mechanisms for autoregulation, but these are incompatible with eukaryotic cell …

Transposons have contributed protein coding sequences to a unexpectedly large number of
human genes. Except for the V (D) J recombinase and telomerase, all remain of unknown …

In this review, we focus on the assembly of DNA/protein complexes that trigger transposition
in eukaryotic members of the IS630–Tc1–mariner (ITm) super-family, the Tc1-and mariner …

The functional relevance of the inverted repeat structure (IR/DR) in a subgroup of the
Tc1/mariner superfamily of transposons has been enigmatic. In contrast to mariner …

Hsmar1 is a member of the mariner family of DNA transposons. Although widespread in
nature, their molecular mechanism remains obscure. Many other cut-and-paste elements …