Neural respiratory drive, ie, the activity of respiratory centres controlling breathing, is an
overlooked physiologic variable which affects the pathophysiology and the clinical outcome …

Mechanical ventilation is the most used short-term life support technique worldwide and is
applied daily for a diverse spectrum of indications, from scheduled surgical procedures to …

Mechanical ventilation can cause acute diaphragm atrophy and injury, and this is associated
with poor clinical outcomes. Although the importance and impact of lung-protective …

Abstract Purpose Esophageal pressure (Pes) is a minimally invasive advanced respiratory
monitoring method with the potential to guide management of ventilation support and …

Diaphragm weakness is highly prevalent in critically ill patients. It may exist prior to ICU
admission and may precipitate the need for mechanical ventilation but it also frequently …

Patients with severe lung injury usually have a high respiratory drive, resulting in intense
inspiratory effort that may even worsen lung damage by several mechanisms gathered …

This report summarizes current physiological and technical knowledge on esophageal
pressure (Pes) measurements in patients receiving mechanical ventilation. The respiratory …

Background Excessive respiratory muscle effort during mechanical ventilation may cause
patient self-inflicted lung injury and load-induced diaphragm myotrauma, but there are no …

During assisted mechanical ventilation, spontaneous inspiratory effort can cause both lung
(patient self-inflicted lung injury [P-SILI]) and diaphragm injury. While clinicians are primarily …

Mechanical ventilation supports gas exchange and alleviates the work of breathing when
the respiratory muscles are overwhelmed by an acute pulmonary or systemic insult …