New insights into the development of the human cerebral cortex
The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …
presumed to be responsible for the neuronal computations underlying complex phenomena …
MAP/ERK signaling in developing cognitive and emotional function and its effect on pathological and neurodegenerative processes
H Albert-Gascó, F Ros-Bernal… - International journal of …, 2020 - mdpi.com
The signaling pathway of the microtubule-associated protein kinase or extracellular
regulated kinase (MAPK/ERK) is a common mechanism of extracellular information …
regulated kinase (MAPK/ERK) is a common mechanism of extracellular information …
Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map
Although the cerebral cortex is organized into six excitatory neuronal layers, it is unclear
whether glial cells show distinct layering. In the present study, we developed a high-content …
whether glial cells show distinct layering. In the present study, we developed a high-content …
Cerebral organoids at the air–liquid interface generate diverse nerve tracts with functional output
SL Giandomenico, SB Mierau, GM Gibbons… - Nature …, 2019 - nature.com
Neural organoids have the potential to improve our understanding of human brain
development and neurological disorders. However, it remains to be seen whether these …
development and neurological disorders. However, it remains to be seen whether these …
Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset
M Heide, C Haffner, A Murayama, Y Kurotaki… - Science, 2020 - science.org
The neocortex has expanded during mammalian evolution. Overexpression studies in
developing mouse and ferret neocortex have implicated the human-specific gene …
developing mouse and ferret neocortex have implicated the human-specific gene …
[HTML][HTML] Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism
Autism spectrum disorder (ASD) is a complex developmental syndrome of unknown
etiology. Recent studies employing exome-and genome-wide sequencing have identified …
etiology. Recent studies employing exome-and genome-wide sequencing have identified …
Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
Microglia, the brain-resident macrophages, exhibit highly dynamic functions in
neurodevelopment and neurodegeneration. Human microglia possess unique features as …
neurodevelopment and neurodegeneration. Human microglia possess unique features as …
Delineation of early brain development from fetuses to infants with diffusion MRI and beyond
Dynamic macrostructural and microstructural changes take place from the mid-fetal stage to
2 years after birth. Delineating structural changes of the brain during early development …
2 years after birth. Delineating structural changes of the brain during early development …
[PDF][PDF] Deterministic progenitor behavior and unitary production of neurons in the neocortex
Radial glial progenitors (RGPs) are responsible for producing nearly all neocortical neurons.
To gain insight into the patterns of RGP division and neuron production, we quantitatively …
To gain insight into the patterns of RGP division and neuron production, we quantitatively …
Bridging barriers: a comparative look at the blood–brain barrier across organisms
NM O'Brown, SJ Pfau, C Gu - Genes & development, 2018 - genesdev.cshlp.org
The blood–brain barrier (BBB) restricts free access of molecules between the blood and the
brain and is essential for regulating the neural microenvironment. Here, we describe how …
brain and is essential for regulating the neural microenvironment. Here, we describe how …