Notch signaling is a conserved system of communication between adjacent cells,
influencing numerous cell fate decisions in the development of multicellular organisms …

Redox signaling regulates physiological self-renewal, proliferation, migration and
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …

Blood vessels define local microenvironments in the skeletal system, play crucial roles in
osteogenesis and provide niches for haematopoietic stem cells,,,,,. The properties of niche …

Monitoring of cell-cell communication in multicellular organisms is fundamental to
understanding diverse biological processes such as embryogenesis and tumorigenesis. To …

Lineage tracing is the identification of all progeny of a single cell. Although its origins date
back to developmental biology of invertebrates in the 19 th century, lineage tracing is now …

The mammalian intestine is covered by a single layer of epithelial cells that is renewed
every 4–5 days. This high cell turnover makes it a very attractive and comprehensive adult …

Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Notch signaling is known to regulate the proliferation and differentiation of intestinal stem
and progenitor cells; however, direct cellular targets and specific functions of Notch signals …

Drug resistance is a major cause for therapeutic failure in non-small cell lung cancer
(NSCLC) leading to tumor recurrence and disease progression. Cell intrinsic mechanisms of …

In this review, we present an overview of intestinal development and cellular differentiation
of the intestinal epithelium. The review is separated into two sections: Section one …