The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

Metformin, one of the oldest oral antidiabetic agents and still recommended by almost all
current guidelines as the first-line treatment for type 2 diabetes mellitus (T2DM), has become …

Diabetic nephropathy (DN) is one of the serious complications in diabetes. Cyanidin-3-
glucoside (C3G) from black rice was reported to have hypoglycemic effects and an anti …

Background and aim Klotho was first identified as a gene associated with aging and
longevity in 1997. α-Klotho is an anti-aging protein and its role in energy metabolism …

Abstract Fibroblast growth factor 21 (FGF21) is a peptide hormone mainly synthesized and
released from the liver. FGF21 acts on FGF21 receptors (FGFRs) and β-Klotho, which is a …

Ethnopharmacological relevance Huangkui capsule (HKC), extracted from Abelmoschus
manihot (L.) medic (AM), as a patent proprietary Chinese medicine on the market for …

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide and
is a significant burden on healthcare systems. α-klotho (klotho) is a protein known for its anti …

Radiotherapy is widely used in clinic due to its good effect for cancer treatment. But
radiotherapy of malignant tumors in the abdomen and pelvis is easy to cause radiation …

Metformin is a frontline hypoglycemic agent, which is mainly prescribed to manage type 2
diabetes mellitus with obesity. Emerging evidence suggests that metformin also exerts …

The aim of the present study was to explore the effects of Dapagliflozin on renal fibrosis in
streptozotocin (STZ)‑induced type 2 diabetes mellitus (T2DM) rats, and to determine the …