Cancer cells accumulate many genetic alterations throughout their lifetime, but only a few of
them drive cancer progression, termed driver mutations. Driver mutations may vary between …

Mutations are the driving force of evolution, yet they underlie many diseases, in particular,
cancer. They are thought to arise from a combination of stochastic errors in DNA processing …

Genome sequencing can be used to detect DNA repair failures in tumors and learn about
underlying mechanisms. Here, we synthesize findings from genomic studies that examined …

Motivation Mutational signatures are a critical component in deciphering the genetic
alterations that underlie cancer development and have become a valuable resource to …

Mutational signature analysis is a recent computational approach for interpreting somatic
mutations in the genome. Its application to cancer data has enhanced our understanding of …

Accurate detection of homologous recombination deficiency (HRD) in cancer patients is
paramount in clinical applications, as HRD confers sensitivity to poly (ADP-ribose) …

Background A deep understanding of carcinogenesis at the DNA level underpins many
advances in cancer prevention and treatment. Mutational signatures provide a breakthrough …

Cancer results from an evolutionary process that yields a heterogeneous tumor with distinct
subpopulations and varying sets of somatic mutations. This perspective discusses …

The advancement of cancer is driven by the accumulation of somatic mutations arising from
various mutational processes within the individual's lifetime. A specific mutational process …

Mutational signatures are the outcomes of mutagenic processes that occur prior to, and
during, tumorigenesis as a result of DNA damage, DNA repair, and DNA replication. In this …