Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Cellular senescence is a heterogeneous process guided by genetic, epigenetic and
environmental factors, characterizing many types of somatic cells. It has been suggested as …

Characterized by nucleus pulposus (NP) cell senescence and extracellular matrix (ECM)
degradation, disc degeneration is a common pathology for various degenerative spinal …

Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …

Cellular senescence is a state of stable growth arrest and a desired outcome of tumor
suppressive interventions. Treatment with many anti‐cancer drugs can cause premature …

The accumulation of senescent cells is a key characteristic of aging, leading to the
progression of age-related diseases such as osteoarthritis (OA). Previous data from our …

Osteoarthritis (OA) has been recognized as an age-related degenerative disease commonly
seen in the elderly that affects the whole “organ” including cartilage, subchondral bone …