Evolution of biochip technology: A review from lab-on-a-chip to organ-on-a-chip
N Azizipour, R Avazpour, DH Rosenzweig, M Sawan… - Micromachines, 2020 - mdpi.com
Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel
biomedical application for microfluidic based devices has emerged in recent years and …
biomedical application for microfluidic based devices has emerged in recent years and …
Organ‐on‐a‐chip platforms: a convergence of advanced materials, cells, and microscale technologies
S Ahadian, R Civitarese, D Bannerman… - Advanced …, 2018 - Wiley Online Library
Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …
[HTML][HTML] The gut–organ-axis concept: Advances the application of gut-on-chip technology
The intestine is considered to be a vital digestive organ to absorb nutrients and is the largest
immune organ, while numerous microorganisms coexist with the host. It is well known that …
immune organ, while numerous microorganisms coexist with the host. It is well known that …
Micro and nanoscale technologies in oral drug delivery
Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to
administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery …
administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery …
Gut-on-a-chip: Current progress and future opportunities
Organ-on-a-chip technology tries to mimic the complexity of native tissues in vitro. Important
progress has recently been made in using this technology to study the gut with and without …
progress has recently been made in using this technology to study the gut with and without …
Advances and Current Challenges in Intestinal in vitro Model Engineering: A Digest
J Costa, A Ahluwalia - Frontiers in bioengineering and biotechnology, 2019 - frontiersin.org
The physiological environment of the intestine is characterized by its variegated
composition, numerous functions and unique dynamic conditions, making it challenging to …
composition, numerous functions and unique dynamic conditions, making it challenging to …
Human biomimetic liver microphysiology systems in drug development and precision medicine
A Gough, A Soto-Gutierrez, L Vernetti… - Nature reviews …, 2021 - nature.com
Microphysiology systems (MPS), also called organs-on-chips and tissue chips, are
miniaturized functional units of organs constructed with multiple cell types under a variety of …
miniaturized functional units of organs constructed with multiple cell types under a variety of …
Chip-based human liver–intestine and liver–skin co-cultures–A first step toward systemic repeated dose substance testing in vitro
I Maschmeyer, T Hasenberg, A Jaenicke… - European journal of …, 2015 - Elsevier
Systemic repeated dose safety assessment and systemic efficacy evaluation of substances
are currently carried out on laboratory animals and in humans due to the lack of predictive …
are currently carried out on laboratory animals and in humans due to the lack of predictive …
Microfluidic organ‐on‐a‐chip technology for advancement of drug development and toxicology
JD Caplin, NG Granados, MR James… - Advanced …, 2015 - Wiley Online Library
In recent years, the exploitation of phenomena surrounding microfluidics has seen an
increase in popularity, as researchers have found a way to use their unique properties to …
increase in popularity, as researchers have found a way to use their unique properties to …
Microfluidic lumen-based systems for advancing tubular organ modeling
Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and
physiology of tubular organs. These technologies can mimic human pathophysiology and …
physiology of tubular organs. These technologies can mimic human pathophysiology and …