Adenine-induced animal model of chronic kidney disease: current applications and future perspectives
Q Yang, S Su, N Luo, G Cao - Renal Failure, 2024 - Taylor & Francis
Chronic kidney disease (CKD) with high morbidity and mortality all over the world is
characterized by decreased kidney function, a condition which can result from numerous risk …
characterized by decreased kidney function, a condition which can result from numerous risk …
Catalpol attenuates oxidative stress and inflammation via mechanisms involving sirtuin-1 activation and NF-κB inhibition in experimentally-induced chronic kidney …
Chronic kidney disease (CKD) is a stealthy disease, and its development is linked to
mechanisms including inflammation and oxidative stress. Catalpol (CAT), an iridoid …
mechanisms including inflammation and oxidative stress. Catalpol (CAT), an iridoid …
Cytoplasmic retention of the DNA/RNA-binding protein FUS ameliorates organ fibrosis in mice
Uncontrolled accumulation of extracellular matrix leads to tissue fibrosis and loss of organ
function. We previously demonstrated in vitro that the DNA/RNA-binding protein fused in …
function. We previously demonstrated in vitro that the DNA/RNA-binding protein fused in …
Ameliorative effect of montelukast against STZ induced diabetic nephropathy: targeting HMGB1, TLR4, NF-κB, NLRP3 inflammasome, and autophagy pathways
Diabetic nephropathy (DN) is reported as one of the most serious microvascular diabetic
complications and the trigger of end-stage renal disease (ESRD), underscoring the concern …
complications and the trigger of end-stage renal disease (ESRD), underscoring the concern …
EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma
Background Epidermal growth factor receptor (EGFR) amplification and TP53 mutation are
the two most common genetic alterations in glioblastoma multiforme (GBM). A …
the two most common genetic alterations in glioblastoma multiforme (GBM). A …
Nephroprotective activity of Aframomum melegueta seeds extract against diclofenac-induced acute kidney injury: A mechanistic study
Abstract Ethnopharmacological relevance In Africa, Aframomum species have been
traditionally used to treat illnesses such as inflammation, hypertension, diarrhea …
traditionally used to treat illnesses such as inflammation, hypertension, diarrhea …
CysLTR1 antagonism by montelukast can ameliorate diabetes-induced aortic and testicular inflammation
Aims Montelukast, a cysteinyl leukotriene receptor (CysLTR) 1 antagonist, is emerging as an
attractive strategy to curtail diabetic complications; however, its role in aortic and testicular …
attractive strategy to curtail diabetic complications; however, its role in aortic and testicular …
Nephroprotective effect of pioglitazone in a Wistar rat model of adenine‑induced chronic kidney disease
MC Pérez-Villalobos… - Experimental and …, 2024 - spandidos-publications.com
Chronic kidney disease (CKD) is a progressive disease with a high mortality rate and a
worldwide prevalence of 13.4%, triggered by various diseases with high incidence. The aim …
worldwide prevalence of 13.4%, triggered by various diseases with high incidence. The aim …
Small-dose sunitinib modulates p53, Bcl-2, STAT3, and ERK1/2 pathways and protects against adenine-induced nephrotoxicity
The therapeutic use of numerous pharmacological agents may be limited due to their
nephrotoxicity and associated kidney injury. The aim of our study is to test the hypothesis …
nephrotoxicity and associated kidney injury. The aim of our study is to test the hypothesis …
Erlotinib regulates short-term memory, tau/Aβ pathology, and astrogliosis in mouse models of AD
H Lee, JW Hwang, J Kim, AR Jo, JH Park… - Frontiers in …, 2024 - frontiersin.org
Introduction Erlotinib is an epidermal growth factor receptor (EGFR) inhibitor that is
approved by the FDA to treat non-small cell lung cancer (NSCLC). Several membrane …
approved by the FDA to treat non-small cell lung cancer (NSCLC). Several membrane …